CASE REPORT: FATAL MULTIORGAN FAILURE AND HETEROCHRONOUS PNEUMONITIS FOLLOWING PEMBROLIZUMAB TREATMENT IN A PATIENT WITH LARGE-CELL NEUROENDOCRINE CARCINOMA OF LUNG

Immune checkpoint OCU-FORCE inhibitors have radically changed the landscape of antitumor therapies in several malignancies.Despite the long-term efficacy, severe immune-related adverse events (irAEs) were not uncommon.However, fatal simultaneous multiorgan failure was rare.Here, we described a patient who developed multiorgan failure, including ful

Abstract Background Very Vacuums long-chain acyl-coenzyme-A dehydrogenase deficiency is a rare, severe life-threatening metabolic disorder of mitochondrial fatty acid oxidation, caused by mutations in ACADVL gene.Here we present a genetically confirmed case of a South Asian baby girl with severe, early-onset form of very long-chain acyl-coenzyme-A

Batteries offer a combination of balancing and regulation services within a smart grid to improve its resilience and flexibility.Maintaining an acceptable state of health and the highest rate of return requires Ringette Tip dynamic modelling of the asset and rigorous optimisation.The authors compare the technical cost and economic benefit of batter

The subjects of the study are the models and methods for providing functionally steady motion control of the small unmanned aerial vehicle (SUAV).The purpose of this work is the development of the method for providing functionally steady motion control of SUAV with a classical, minimally necessary composition of measuring sensors without hardware r

The complexity of researching traffic under extraordinaryconditions in order to implement a more efficient and functionaltraffic management strategy under both normal and irregularconditions- as well as the grey zone of when the changefrom normal into extraordinary Console traffic conditions actually occur-provides the researcher with numerous meth